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Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context.

Abstract:

There are 14 unconfounded randomised trials of antihypertensive drugs (chiefly diuretics or beta-blockers): total 37,000 individuals, mean treatment duration 5 years, mean diastolic blood pressure (DBP) difference 5-6 mm Hg. In prospective observational studies, a long-term difference of 5-6 mm Hg in usual DBP is associated with about 35-40% less stroke and 20-25% less coronary heart disease (CHD). For those dying in the trials, the DBP difference had persisted only 2-3 years, yet an overview...

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Publication status:
Published

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Authors


Collins, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
MacMahon, S More by this author
Fiebach, NH More by this author
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Journal:
Lancet
Volume:
335
Issue:
8693
Pages:
827-838
Publication date:
1990-04-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:56b4c5a0-0527-463b-b26c-9cdbb5888adc
Source identifiers:
43275
Local pid:
pubs:43275

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