Journal article
Novel pathogenic antibodies give insight into the role of GABA A receptors in the central nervous system
- Abstract:
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- Antibodies against the β3 subunit of GABAA receptors identified in patients with thymomas.
- Spectrum of autoimmune encephalitides extended with discovery of pathogenic antibodies to inhibitory channel.
- Identification of antibodies involved a comprehensive characterisation of pathogenicity.
- Clinically, improvement is observed but coincides with multiple interventions and does not directly address whether this may be due to a depression in autoantibody titres.
- Binding of antibodies may alter network excitability, as inhibitory neurotransmission is likely to be impaired.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 654.5KB, Terms of use)
-
- Publisher copy:
- 10.47795/OZLW9498
Authors
- Publisher:
- Whitehouse Publishing
- Journal:
- Advances in Clinical Neuroscience and Rehabilitation More from this journal
- Volume:
- 14
- Issue:
- 5
- Pages:
- 22-24
- Publication date:
- 2014-09-30
- Acceptance date:
- 2014-09-30
- DOI:
- EISSN:
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2397-267X
- ISSN:
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1473-9348
- Language:
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English
- Pubs id:
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pubs:659137
- UUID:
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uuid:56a48ca8-622e-4273-8e70-a2f4669702f5
- Local pid:
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pubs:659137
- Deposit date:
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2016-11-13
- ARK identifier:
Terms of use
- Copyright holder:
- Menassa and Bera
- Copyright date:
- 2014
- Rights statement:
- © 2014 The Authors. This work is licensed under a Creative Commons Attribution 4.0 License.
- Licence:
- CC Attribution (CC BY)
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