Journal article

Interferon-stimulated gene products as regulators of central carbon metabolism

Abstract:: In response to viral infections, the innate immune system rapidly activates expression of several interferon‐stimulated genes (ISGs), whose protein and metabolic products are believed to directly interfere with the viral life cycle. Here, we argue that biochemical reactions performed by two specific protein products of ISGs modulate central carbon metabolism to support a broad‐spectrum antiviral response. We demonstrate that the metabolites generated by metalloenzymes nitric oxide synthase and the radical S‐adenosylmethionine (SAM) enzyme RSAD2 inhibit the activity of the housekeeping and glycolytic enzyme glyceraldehyde 3‐phosphate dehydrogenase (GAPDH). We discuss that this inhibition is likely to stimulate a range of metabolic and signalling processes to support a broad‐spectrum immune response. Based on these analyses, we propose that inhibiting GAPDH in individuals with deteriorated cellular innate immune response like elderly might help in treating viral diseases such as COVID‐19.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Honarmand Ebrahimi, K., Gilbert Jaramillo, J., James, W. S., & McCullagh, J. S. O. (2020). Interferon-stimulated gene products as regulators of central carbon metabolism. FEBS Journal, 288(12), 3715–3726.

MLA Style

Honarmand Ebrahimi, K., et al. “Interferon-Stimulated Gene Products as Regulators of Central Carbon Metabolism.” FEBS Journal, vol. 288, no. 12, Wiley, 2020, pp. 3715–26.

Chicago Style

Honarmand Ebrahimi, K, J Gilbert Jaramillo, WS James, and JSO McCullagh. 2020. “Interferon-Stimulated Gene Products as Regulators of Central Carbon Metabolism.” FEBS Journal 288 (12): 3715–26.
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Files:: Ebrahimi et al 2020 Interferon-stimulated gene products.pdf

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Publisher copy:: 10.1111/febs.15625

Authors

+ Honarmand Ebrahimi, K More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Role:: Author

+ Gilbert Jaramillo, J More by this author

Role:: Author

+ James, WS More by this author

Institution:: University of Oxford
Division:: MSD
Sub department:: BV PATHOLOGY DUNN SCHOOL; JR UNIVERSITY OFFICERS
Role:: Author
ORCID:: 0000-0002-2506-1198

+ McCullagh, JSO More by this author

Institution:: University of Oxford
Department:: CHEMISTRY
Sub department:: Chemistry
Oxford college:: Merton College
Role:: Author
ORCID:: 0000-0003-4733-1205

Publisher:: Wiley
Journal:: FEBS Journal More from this journal
Volume:: 288
Issue:: 12
Pages:: 3715-3726
Place of publication:: England
Publication date:: 2020-12-01
Acceptance date:: 2020-11-09
DOI:: 10.1111/febs.15625
EISSN:: 1742-4658
ISSN:: 1742-464X
Pmid:: 33185982

Language:: English
Keywords:: ISG

FFR

viruses

immunometabolism

GAPDH

viperin
Pubs id:: 1146908
Local pid:: pubs:1146908
Deposit date:: 2020-12-09

Terms of use

Copyright holder:: Ebrahimi et al.
Copyright date:: 2020
Rights statement:: © The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Licence:: CC Attribution (CC BY)

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