Journal article
A novel scoring system for prediction of disease severity in COVID-19
- Abstract:
- Background: A novel enveloped RNA beta coronavirus, Corona Virus Disease 2019 (COVID-19) caused severe and even fetal pneumonia in China and other countries from December 2019. Early detection of severe patients with COVID-19 is of great significance to shorten the disease course and reduce mortality. Methods: We assembled a retrospective cohort of 80 patients (including 56 mild and 24 severe) with COVID-19 infection treated at Beijing You'an Hospital. We used univariable and multivariable logistic regression analyses to select the risk factors of severe and even fetal pneumonia and build scoring system for prediction, which was validated later on in a group of 22 COVID-19 patients. Results: Age, white blood cell count, neutrophil, glomerular filtration rate, and myoglobin were selected by multivariate analysis as candidates of scoring system for prediction of disease severity in COVID-19. The scoring system was applied to calculate the predictive value and found that the percentage of ICU admission (20%, 6/30) and ventilation (16.7%, 5/30) in patients with high risk was much higher than those (2%, 1/50; 2%, 1/50) in patients with low risk (p = 0.009; p = 0.026). The AUC of scoring system was 0.906, sensitivity of prediction is 70.8%, and the specificity is 89.3%. According to scoring system, the probability of patients in high risk group developing severe disease was 20.24 times than that in low risk group. Conclusions: The possibility of severity in COVID-19 infection predicted by scoring system could help patients to receiving different therapy strategies at a very early stage.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Accepted manuscript, pdf, 437.4KB, Terms of use)
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- Publisher copy:
- 10.3389/fcimb.2020.00318
Authors
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Cellular and Infection Microbiology More from this journal
- Publication date:
- 2020-06-05
- Acceptance date:
- 2020-05-25
- DOI:
- EISSN:
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2235-2988
- Keywords:
- Subjects:
- Pubs id:
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1106712
- Local pid:
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pubs:1106712
- Deposit date:
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2020-06-03
- ARK identifier:
Terms of use
- Copyright holder:
- Zhang, Qin, Li, Wang, Zhao, Xu, Liang, Dai, Feng, Sun, Li, Hu, Xiang, Dong, Jin and Zhang.
- Copyright date:
- 2020
- Rights statement:
- Copyright © 2020 Zhang, Qin, Li, Wang, Zhao, Xu, Liang, Dai, Feng, Sun, Li, Hu, Xiang, Dong, Jin and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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