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Kupffer cell staining by an HFE-specific monoclonal antibody: implications for hereditary haemochromatosis.

Abstract:

Hereditary haemochromatosis is an inherited disorder of iron absorption that leads to excessive iron storage in the liver and other organs. A candidate disease gene HFE has been identified that encodes a novel MHC class I like protein. We report the development of a monoclonal antibody (HFE-JB1) specific for recombinant refolded HFE protein. The antibody immunoprecipitates a 49 kD protein from the cell line U937, a histiocytic lymphoma. It binds HFE but does not recognize other recombinant no...

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Authors


Bastin, JM More by this author
O'Callaghan, CA More by this author
Schimanski, L More by this author
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Journal:
British journal of haematology
Volume:
103
Issue:
4
Pages:
931-941
Publication date:
1998-12-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:568d4cb1-541c-4b70-8cb0-5280ceee258f
Source identifiers:
7290
Local pid:
pubs:7290

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