- Abstract:
-
Hereditary haemochromatosis is an inherited disorder of iron absorption that leads to excessive iron storage in the liver and other organs. A candidate disease gene HFE has been identified that encodes a novel MHC class I like protein. We report the development of a monoclonal antibody (HFE-JB1) specific for recombinant refolded HFE protein. The antibody immunoprecipitates a 49 kD protein from the cell line U937, a histiocytic lymphoma. It binds HFE but does not recognize other recombinant no...
Expand abstract - Publisher copy:
- 10.1046/j.1365-2141.1998.01102.x
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- Journal:
- British journal of haematology
- Volume:
- 103
- Issue:
- 4
- Pages:
- 931-941
- Publication date:
- 1998-12-05
- DOI:
- EISSN:
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1365-2141
- ISSN:
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0007-1048
- URN:
-
uuid:568d4cb1-541c-4b70-8cb0-5280ceee258f
- Source identifiers:
-
7290
- Local pid:
- pubs:7290
- Copyright date:
- 1998
Journal article
Kupffer cell staining by an HFE-specific monoclonal antibody: implications for hereditary haemochromatosis.
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