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GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus.

Abstract:

SLC2A2 encoding glucose transporter -2 (GLUT2) acts as the primary glucose transporter and sensor in rodent pancreatic islets and is widely assumed to play a similar role in humans. In healthy adults SLC2A2 variants are associated with elevated fasting plasma glucose (fpg) concentrations but physiological characterisation does not support a defect in pancreatic beta-cell function. Interspecies differences can create barriers for the follow up of disease association signals. We hypothesised th...

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Publication status:
Published

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Publisher copy:
10.1016/j.ymgme.2011.08.026

Authors


McCulloch, LJ More by this author
van de Bunt, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
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Journal:
Molecular genetics and metabolism
Volume:
104
Issue:
4
Pages:
648-653
Publication date:
2011-12-05
DOI:
EISSN:
1096-7206
ISSN:
1096-7192
URN:
uuid:56874ba9-5cd0-4f61-8804-ddf226d79736
Source identifiers:
175238
Local pid:
pubs:175238

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