GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus.

Journal article

SLC2A2 encoding glucose transporter -2 (GLUT2) acts as the primary glucose transporter and sensor in rodent pancreatic islets and is widely assumed to play a similar role in humans. In healthy adults SLC2A2 variants are associated with elevated fasting plasma glucose (fpg) concentrations but physiological characterisation does not support a defect in pancreatic beta-cell function. Interspecies differences can create barriers for the follow up of disease association signals. We hypothesised th...

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Authors: McCulloch, L; van de Bunt, M; Braun, M; Frayn, K; Clark, A

• Publication status: Published
• Journal: Molecular genetics and metabolism
• Volume: 104
• Issue: 4
• Pages: 648-653
• Publication date: 2011-12-01
• DOI: 10.1016/j.ymgme.2011.08.026
• EISSN: 1096-7206
• ISSN: 1096-7192
• Language: English
• Keywords: Animals; Glucose Transporter Type 2; Liver; Glucose Transporter Type 3; Muscle, Skeletal; Humans; Gene Expression; Mice; Genetic Loci; Insulin-Secreting Cells; Subcutaneous Fat; Adipose Tissue, Brown; Glucose Transporter Type 1; RNA, Messenger