Journal article
Synthesis of fluorinated alkyl aryl ethers by palladium-catalyzed C–O cross-coupling
- Abstract:
- Herein, we report a highly effective protocol for the cross-coupling of (hetero)aryl bromides with fluorinated alcohols using the commercially available precatalyst tBuBrettPhos Pd G3 and Cs2CO3 in toluene. This Pd-catalyzed coupling features a short reaction time, excellent functional group tolerance, and compatibility with electron-rich and -poor (hetero)arenes. The method provides access to 18F-labeled trifluoroethyl ethers by cross-coupling with [18F]trifluoroethanol.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 922.5KB, Terms of use)
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- Publisher copy:
- 10.1021/acs.orglett.0c02347
Authors
- Publisher:
- American Chemical Society
- Journal:
- Organic Letters More from this journal
- Volume:
- 22
- Issue:
- 16
- Pages:
- 6573–6577
- Publication date:
- 2020-08-04
- Acceptance date:
- 2020-07-27
- DOI:
- EISSN:
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1523-7052
- ISSN:
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1523-7060
- Language:
-
English
- Keywords:
- Pubs id:
-
1123567
- Local pid:
-
pubs:1123567
- Deposit date:
-
2020-08-05
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2020
- Rights statement:
- © 2020 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
- Licence:
- CC Attribution (CC BY)
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