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Aggressive pituitary tumours: the role of temozolomide and the assessment of MGMT status.

Abstract:

BACKGROUND: Aggressive pituitary tumours are associated with substantial morbidity and mortality. Treatment options are often limited, and chemotherapy has been reserved as salvage therapy although historically results have often been disappointing. However, temozolomide, an oral alkylating agent, has recently demonstrated significant activity against these tumours. A DNA repair protein, 06-methylguanine-DNA methyltransferase (MGMT) has been suggested as a biomarker to predict response to te...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


McCormack, AI More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Publisher:
Wiley Publisher's website
Journal:
European journal of clinical investigation Journal website
Volume:
41
Issue:
10
Pages:
1133-1148
Publication date:
2011-10-05
DOI:
EISSN:
1365-2362
ISSN:
0014-2972
URN:
uuid:5650c2b1-009b-4f56-a3cb-31f8fdb95405
Source identifiers:
134942
Local pid:
pubs:134942

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