Journal article icon

Journal article

Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype.

Abstract:

While human embryonic stem cells (hESCs) may one day facilitate the treatment of degenerative diseases requiring cell replacement therapy, the success of regenerative medicine is predicated on overcoming the rejection of replacement tissues. Given the role played by dendritic cells (DCs) in the establishment of immunological tolerance, we have proposed that DC, rendered tolerogenic during their differentiation from hESC, might predispose recipients to accept replacement tissues. As a first st...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1155/2012/172420

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of biomedicine and biotechnology
Volume:
2012
Pages:
172420
Publication date:
2012-01-01
DOI:
EISSN:
1110-7251
ISSN:
1110-7243
URN:
uuid:561efc39-084b-41d5-a3e1-fa32b2ab511a
Source identifiers:
321709
Local pid:
pubs:321709

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP