Journal article
Antigen-driven differentiation of naive Ig-transgenic B cells in vitro.
- Abstract:
-
We have established a culture system in which naive B cells bearing a transgenic, chicken OVA (cOVA)-specific Ig differentiate to plasma cells in vitro after interaction with cOVA plus cOVA-specific helper T cells. B cell-enriched populations from Ig-transgenic mice, but not from nontransgenic mice, proliferated after presenting nanomolar concentrations of cross-linked cOVA to DO11.10 (cOVA plus IAd-specific) T cells. After 6 to 9 days of culture with Ag and specific T cells, the B cells acqu...
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Bibliographic Details
- Journal:
- Journal of Immunology
- Volume:
- 154
- Issue:
- 10
- Pages:
- 4936-4949
- Publication date:
- 1995-05-01
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Source identifiers:
-
483512
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:483512
- UUID:
-
uuid:5607adc7-02c0-4560-88c9-dc1835d71b70
- Local pid:
- pubs:483512
- Deposit date:
- 2014-09-11
Terms of use
- Copyright date:
- 1995
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