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Antigen-driven differentiation of naive Ig-transgenic B cells in vitro.

Abstract:

We have established a culture system in which naive B cells bearing a transgenic, chicken OVA (cOVA)-specific Ig differentiate to plasma cells in vitro after interaction with cOVA plus cOVA-specific helper T cells. B cell-enriched populations from Ig-transgenic mice, but not from nontransgenic mice, proliferated after presenting nanomolar concentrations of cross-linked cOVA to DO11.10 (cOVA plus IAd-specific) T cells. After 6 to 9 days of culture with Ag and specific T cells, the B cells acqu...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of Immunology
Volume:
154
Issue:
10
Pages:
4936-4949
Publication date:
1995-05-01
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
483512

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