Journal article
Drug delivery strategies for antibiofilm therapy
- Abstract:
- Although new antibiofilm agents have been developed to prevent and eliminate pathogenic biofilms, their widespread clinical use is hindered by poor biocompatibility and bioavailability, unspecific interactions and insufficient local concentrations. The development of innovative drug delivery strategies can facilitate penetration of antimicrobials through biofilms, promote drug dispersal and synergistic bactericidal effects, and provide novel paradigms for clinical application. In this Review, we discuss the potential benefits of such emerging techniques for improving the clinical efficacy of antibiofilm agents, as well as highlighting the existing limitations and future prospects for these therapies in the clinic.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 1.2MB, Terms of use)
-
- Publisher copy:
- 10.1038/s41579-023-00905-2
Authors
- Publisher:
- Springer Nature
- Journal:
- Nature Reviews Microbiology More from this journal
- Volume:
- 21
- Issue:
- 9
- Pages:
- 555-572
- Publication date:
- 2023-05-31
- Acceptance date:
- 2023-04-28
- DOI:
- EISSN:
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1740-1534
- ISSN:
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1740-1526
- Language:
-
English
- Keywords:
- Pubs id:
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1340745
- Local pid:
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pubs:1340745
- Deposit date:
-
2023-05-11
Terms of use
- Copyright holder:
- Springer Nature Limited
- Copyright date:
- 2023
- Rights statement:
- Copyright © 2023, Springer Nature Limited
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Springer Nature at https://dx.doi.org/10.1038/s41579-023-00905-2
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