[Cardiac energy metabolism in heart valve diseases with 31P MR spectroscopy]

Beer, M; Viehrig, M; Seyfarth, T; Sandstede, J; Lipke, C; Pabst, T; Kenn, W; Harre, K; Horn, M; Landschütz, W; von Kienlin, M; Neubauer, S; Hahn, D

Journal article

[Cardiac energy metabolism in heart valve diseases with 31P MR spectroscopy]

Abstract:: PURPOSE: Heart valve disease combined with left ventricular hypertrophy leads to derangements in cardiac energy metabolism, which can be detected non-invasively by 31P-MR-spectroscopy. The purpose of the present study was to examine whether the derangements in cardiac metabolism are reversible after surgical valve replacement. PATIENTS AND METHODS: 10 healthy volunteers and 10 patients with aortic stenosis (pressure gradients > 60 mmHg) were included. For assessment of energy metabolism, 31P-MR spectra were obtained with a double oblique 3D-CSI technique (voxel size 25 cm3). In 5 of 10 patients, follow-up examination was performed 3 months after surgical valve replacement (SVR). Left ventricular (LV) function was analyzed by cine MRI. RESULTS: Before SVR the myocardial phosphocreatine to adenosinetriphosphate (PCr-ATP) ratio was significantly (p = 0.0002) reduced to 0.80 +/- 0.25 in patients compared to 1.65 +/- 0.21 in volunteers. 3 months after SVR, LV mass had significantly (p = 0.04) decreased from 238 +/- 33 g to 206 +/- 47 g. At the same time a significant (p = 0.04) increase of the PCr-ATP ratio from 0.80 +/- 0.25 to 1.28 +/- 0.22 was observed. A slight, but not significant, reduction of the phosphodiester ATP ratio was observed before SVR, with a trend towards normalization after SVR. CONCLUSIONS: After SVR, the deranged energy metabolism shows a trend towards normalization. Further follow-up is necessary to determine whether complete normalization of the energetic derangement can be observed over longer periods of time following SVR.

Publication status:: Published

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APA Style

Beer, M., Viehrig, M., Seyfarth, T., Sandstede, J., Lipke, C., Pabst, T., Kenn, W., Harre, K., Horn, M., Landschütz, W., von Kienlin, M., Neubauer, S., & Hahn, D. (2000). [Cardiac energy metabolism in heart valve diseases with 31P MR spectroscopy]. Der Radiologe, 40(2), 162–167.

MLA Style

Beer, M., et al. “[Cardiac Energy Metabolism in Heart Valve Diseases with 31P MR Spectroscopy].” Der Radiologe, vol. 40, no. 2, 2000, pp. 162–67.

Chicago Style

Beer, M, M Viehrig, T Seyfarth, J Sandstede, C Lipke, T Pabst, W Kenn, et al. 2000. “[Cardiac Energy Metabolism in Heart Valve Diseases with 31P MR Spectroscopy].” Der Radiologe 40 (2): 162–67.
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