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Correlating structure and function in ATP-sensitive K+ channels.

Abstract:

ATP-sensitive K+ channels couple cell metabolism to electrical activity in nerve, muscle and endocrine cells, and play important roles in these tissues under both physiological and pathological conditions. The KATP channel is an octameric complex of two unrelated types of subunit: a pore-forming subunit (Kir6.2) and a regulatory subunit, the sulphonylurea receptor (SUR). This review focuses on the regulation of KATP channel activity by nucleotides and cell metabolism and considers which regul...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Trends in neurosciences
Volume:
21
Issue:
7
Pages:
288-294
Publication date:
1998-07-05
DOI:
EISSN:
1878-108X
ISSN:
0166-2236
URN:
uuid:55da852c-2603-4e46-8dd1-f33623d2c5c0
Source identifiers:
113659
Local pid:
pubs:113659

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