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Characterization of a mitochondrial-targeting signal in the PB2 protein of influenza viruses.

Abstract:

Influenza virus RNA polymerase is a heterotrimeric complex consisting of PB1, PB2, and PA subunits. These polymerase subunits accumulate in the nucleus of infected cells. We report here that PB2, from both human and avian influenza viruses, could also localize to mitochondria in transfected cells. Importantly, cells infected with influenza A virus also displayed mitochondrial PB2. We show that an N-terminal motif composed of 120 amino acids is sufficient for localization of PB2 to mitochondri...

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Publication status:
Published

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Publisher copy:
10.1016/j.virol.2005.08.041

Authors


Carnero, E More by this author
García-Sastre, A More by this author
Brownlee, GG More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Virology
Volume:
344
Issue:
2
Pages:
492-508
Publication date:
2006-01-05
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
URN:
uuid:55b19250-2017-4dcd-a54a-34c1eab75545
Source identifiers:
15472
Local pid:
pubs:15472

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