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Salmonella exploits HLA-B27 and host unfolded protein responses to promote intracellular replication

Abstract:

OBJECTIVE:Salmonella enterica infections can lead to Reactive Arthritis (ReA), which can exhibit an association with human leucocyte antigen (HLA)-B*27:05, a molecule prone to misfolding and initiation of the unfolded protein response (UPR). This study examined how HLA-B*27:05 expression and the UPR affect the Salmonella life-cycle within epithelial cells. METHODS:Isogenic epithelial cell lines expressing two copies of either HLA-B*27:05 and a control HLA-B*35:01 heavy chain (HC) were generat...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1136/annrheumdis-2018-213532

Authors


Antoniou, AN More by this author
More by this author
ORCID:
0000-0002-0149-145X
Iwawaki, T More by this author
Turmaine, M More by this author
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Publisher:
BMJ Publishing Group Publisher's website
Journal:
Annals of the Rheumatic Diseases Journal website
Volume:
78
Issue:
1
Pages:
74-82
Publication date:
2018-10-24
Acceptance date:
2018-07-27
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
Pubs id:
pubs:934906
URN:
uri:55995ea8-c765-4945-9491-28a39a9f4bdb
UUID:
uuid:55995ea8-c765-4945-9491-28a39a9f4bdb
Local pid:
pubs:934906

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