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Secondary cytogenetic aberrations in childhood Philadelphia chromosome positive acute lymphoblastic leukemia are nonrandom and may be associated with outcome.

Abstract:

Additional chromosomal aberrations occur frequently in Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) of childhood. The treatment outcome of these patients is heterogeneous. This study assessed whether such clinical heterogeneity could be partially explained by the presence and characteristics of additional chromosomal abnormalities. Cytogenetic descriptions were available for 249 of 326 children with Ph+ ALL, diagnosed and treated by 10 different study groups/large...

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Publication status:
Published

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Publisher copy:
10.1038/sj.leu.2403324

Authors


Heerema, NA More by this author
Harbott, J More by this author
Galimberti, S More by this author
Camitta, BM More by this author
Gaynon, PS More by this author
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Journal:
Leukemia
Volume:
18
Issue:
4
Pages:
693-702
Publication date:
2004-04-05
DOI:
EISSN:
1476-5551
ISSN:
0887-6924
URN:
uuid:55723d0e-5830-4392-8658-6aa205f63c75
Source identifiers:
39051
Local pid:
pubs:39051

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