Growth hormone replacement does not increase serum prostate-specific antigen in hypopituitary men over 50 years.

Journal article

OBJECTIVE: Epidemiological studies have shown an increased risk for prostate carcinoma in men with serum IGF-I in the upper part of the age-related reference range. Recombinant human GH (rhGH) is widely used in patients with GH deficiency, usually raising the serum IGF-I levels into the normal range: safety surveillance is therefore mandatory, with particular regard to neoplasia. The aim was to examine whether rhGH replacement in hypopituitary adults is associated with changes in serum prostate-specific antigen (PSA) as a surrogate marker of changes in prostatic growth. DESIGN AND METHODS: A prospective longitudinal study was used with a median follow-up of 22 (range 2.5-32) months, in which 41 men aged over 50 years with adult onset hypopituitarism and GH deficiency during rhGH replacement were examined. Serum PSA and IGF-I were measured at baseline and at latest follow-up. RESULTS: Mean serum PSA remained unchanged during rhGH replacement, with a median follow-up of 2 years. No correlation was found between the individual changes in serum IGF-I and changes in serum PSA. CONCLUSIONS: These data are reassuring thus far regarding the safety of GH replacement in relation to the prostate in this patient group.

Authors: le Roux, C; Jenkins, P; Chew, S; Camacho-Hübner, C; Grossman, AB

• Publication status: Published
• Journal: European journal of endocrinology / European Federation of Endocrine Societies
• Volume: 147
• Issue: 1
• Pages: 59-63
• Publication date: 2002-07-01
• DOI: 10.1530/eje.0.1470059
• EISSN: 1479-683X
• ISSN: 0804-4643
• Language: English
• Keywords: Prostate-Specific Antigen; Prospective Studies; Insulin-Like Growth Factor I; Male; Hypopituitarism; Humans; Aged; Middle Aged; Longitudinal Studies; Human Growth Hormone; Follow-Up Studies