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Successful isolation of a rat chromosome 1 blood pressure quantitative trait locus in reciprocal congenic strains.

Abstract:

Linkage analyses in experimental crosses of hypertensive and normotensive rats have strongly suggested the presence of a quantitative trait locus (QTL) influencing blood pressure on rat chromosome 1, at or near the Sa gene. To confirm the presence of such a locus and move toward identification of the causative gene, we have developed, through targeted breeding over 10 generations using an Sa gene polymorphism to select breeders at each generation, 2 congenic strains, 1 containing a segment of...

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Publication status:
Published

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Publisher copy:
10.1161/01.hyp.32.4.639

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Hypertension
Volume:
32
Issue:
4
Pages:
639-646
Publication date:
1998-10-01
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
Source identifiers:
4343
Language:
English
Keywords:
Pubs id:
pubs:4343
UUID:
uuid:5543dfb2-1e95-46c4-8e2d-b3db45681f2a
Local pid:
pubs:4343
Deposit date:
2012-12-19

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