Successful isolation of a rat chromosome 1 blood pressure quantitative trait locus in reciprocal congenic strains.

Journal article

Linkage analyses in experimental crosses of hypertensive and normotensive rats have strongly suggested the presence of a quantitative trait locus (QTL) influencing blood pressure on rat chromosome 1, at or near the Sa gene. To confirm the presence of such a locus and move toward identification of the causative gene, we have developed, through targeted breeding over 10 generations using an Sa gene polymorphism to select breeders at each generation, 2 congenic strains, 1 containing a segment of...

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Authors: Frantz, SA; Kaiser, M; Gardiner, S; Gauguier, D; Vincent, M

• Publication status: Published
• Journal: Hypertension
• Volume: 32
• Issue: 4
• Pages: 639-646
• Publication date: 1998-10-01
• DOI: 10.1161/01.hyp.32.4.639
• EISSN: 1524-4563
• ISSN: 0194-911X
• Language: English
• Keywords: Blood Pressure; Genotype; Hypertension; Rats, Inbred WKY; Male; Chromosome Mapping; Rats, Inbred SHR; Quantitative Trait, Heritable; Animals, Congenic; Rats; Animals; Lod Score