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Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis.

Abstract:

Arthritis is characterised by the proteolytic degradation of articular cartilage leading to a loss of joint function. Articular cartilage is composed of an extracellular matrix of proteoglycans and collagens. We have previously shown that serine proteinases are involved in the activation cascades leading to cartilage collagen degradation. The aim of this study was to use an active-site probe, biotinylated fluorophosphonate, to identify active serine proteinases present on the chondrocyte memb...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1186/ar1877

Authors


Milner, JM More by this author
Kevorkian, L More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Arthritis research and therapy Journal website
Volume:
8
Issue:
1
Pages:
R23
Publication date:
2006
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
URN:
uuid:55382c11-b6ca-4ec5-8e63-c04759a439c7
Source identifiers:
229149
Local pid:
pubs:229149

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