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Overexpression of heme oxygenase-1 protects allogeneic thyroid grafts from rejection in naive mice.

Abstract:

BACKGROUND: Endocrine allografts are an option for the treatment of endocrine failure. METHODS: One lobe of the thyroid was transplanted under the kidney capsule. RESULTS: C57BL/10 (H2(b)) thyroids were rejected in naive CBA (H2(k)) mice within 14 days after transplantation. When mice were treated with anti-CD4 monoclonal antibodies (mAb), all grafts survived for more than 60 days. The first grafts still survived after second C57BL/10 or Balb/c (H2(d)) thyroid grafts that were transplanted in...

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Publication status:
Published

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Publisher copy:
10.1067/msy.2000.109968

Authors


Takashina, M More by this author
Shatari, T More by this author
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Volume:
128
Issue:
6
Pages:
910-917
Publication date:
2000-12-05
DOI:
EISSN:
1532-7361
ISSN:
0039-6060
URN:
uuid:550644a2-b5f5-46e9-a209-a4fe015bfe95
Source identifiers:
136041
Local pid:
pubs:136041

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