Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.

Journal article

Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain-carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptomes of 1043 P. falciparum isolates from patients with acute malaria and found that artemisinin resistance is associated with increased expression of unfolded protein response (UPR) pathways involving the...

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Authors: Mok, S; Ashley, E; Ferreira, P; Zhu, L; Lin, Z

• Publication status: Published
• Journal: Science (New York, N.Y.)
• Volume: 347
• Issue: 6220
• Pages: 431-435
• Publication date: 2015-01-01
• DOI: 10.1126/science.1260403
• EISSN: 1095-9203
• ISSN: 0036-8075
• Language: English
• Keywords: Unfolded Protein Response; Malaria, Falciparum; Animals; Transcriptome; Antimalarials; Chaperonin Containing TCP-1; Humans; Drug Resistance; Artemisinins; Malaria; Plasmodium falciparum