Production of cytokines, vascular endothelial growth factor, matrix metalloproteinases, and tissue inhibitor of metalloproteinases 1 by tenosynovium demonstrates its potential for tendon destruction in rheumatoid arthritis.

Journal article

OBJECTIVE: To investigate the role of proinflammatory cytokines, vascular endothelial growth factor (VEGF), matrix metalloproteinases (MMPs), and tissue inhibitor of metalloproteinases 1 (TIMP-1) in the destruction of tendons by tenosynovium in rheumatoid arthritis (RA). METHODS: Synovial specimens were obtained from encapsulating tenosynovium (n = 17), invasive tenosynovium (n = 13), and wrist joints (n = 17) in 18 RA patients undergoing wrist extensor tenosynovectomy. Synovial membrane cell...

Expand abstract

Authors: Jain, A; Nanchahal, J; Troeberg, L; Green, P; Brennan, F

• Publication status: Published
• Journal: Arthritis and rheumatism
• Volume: 44
• Issue: 8
• Pages: 1754-1760
• Publication date: 2001-08-01
• DOI: 10.1002/1529-0131(200108)44:8<1754::AID-ART310>3.0.CO;2-8
• EISSN: 1529-0131
• ISSN: 0004-3591
• Language: English
• Keywords: Synovial Membrane; Cells, Cultured; Humans; Vascular Endothelial Growth Factor A; Tissue Inhibitor of Metalloproteinase-1; Arthritis, Rheumatoid; Adult; Middle Aged; Aged; Female; Male; Wrist Joint; Lymphokines; Vascular Endothelial Growth Factors; Matrix Metalloproteinases; Tendons; Endothelial Growth Factors; Cytokines