Journal article
Reversible changes in pancreatic islet structure and function produced by elevated blood glucose
- Abstract:
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Diabetes is characterized by hyperglycaemia due to impaired insulin secretion and aberrant glucagon secretion resulting from changes in pancreatic islet cell function and/or mass. The extent to which hyperglycaemia per se underlies these alterations remains poorly understood. Here we show that β-cell-specific expression of a human activating KATP channel mutation in adult mice leads to rapid diabetes and marked alterations in islet morphology, ultrastructure and gene expression. Chronic hyper...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.0MB)
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- Publisher copy:
- 10.1038/ncomms5639
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Authors
Bibliographic Details
- Publisher:
- Nature publishing Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 5
- Article number:
- 4639
- Publication date:
- 2014-08-22
- Acceptance date:
- 2014-07-10
- DOI:
- ISSN:
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2041-1723
- Pmid:
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25145789
- Source identifiers:
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481516
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:481516
- UUID:
-
uuid:54b07831-5128-406b-bbe7-5aa7af26c057
- Local pid:
- pubs:481516
- Deposit date:
- 2017-10-02
Terms of use
- Copyright holder:
- Macmillan Publishers Limited
- Copyright date:
- 2014
- Notes:
- ©2014 Macmillan Publishers Limited. All rights reserved. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.
- Licence:
- CC Attribution (CC BY)
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