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Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

Abstract:

Diabetes is characterized by hyperglycaemia due to impaired insulin secretion and aberrant glucagon secretion resulting from changes in pancreatic islet cell function and/or mass. The extent to which hyperglycaemia per se underlies these alterations remains poorly understood. Here we show that β-cell-specific expression of a human activating KATP channel mutation in adult mice leads to rapid diabetes and marked alterations in islet morphology, ultrastructure and gene expression. Chronic hyper...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms5639

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
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Publisher:
Nature publishing Publisher's website
Journal:
Nature Communications Journal website
Volume:
5
Article number:
4639
Publication date:
2014-08-22
Acceptance date:
2014-07-10
DOI:
ISSN:
2041-1723
Pmid:
25145789
Source identifiers:
481516

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