- Abstract:
-
Lens epithelium-derived growth factor (LEDGF) fusion proteins can direct HIV-1 DNA integration to novel sites in the host genome. The C terminus of LEDGF contains an integrase binding domain (IBD), and the N terminus binds chromatin. LEDGF normally directs integrations to the bodies of expressed genes. Replacing the N terminus of LEDGF with chromatin binding domains (CBDs) from other proteins changes the specificity of HIV-1 DNA integration. We chose two well-characterized CBDs: the plant hom...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.0914142107
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 107
- Issue:
- 7
- Pages:
- 3135-3140
- Publication date:
- 2010-02-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:548a7c59-37ca-49e0-85ac-8857313086d1
- Source identifiers:
-
331913
- Local pid:
- pubs:331913
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.
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