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Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.

Abstract:

Lens epithelium-derived growth factor (LEDGF) fusion proteins can direct HIV-1 DNA integration to novel sites in the host genome. The C terminus of LEDGF contains an integrase binding domain (IBD), and the N terminus binds chromatin. LEDGF normally directs integrations to the bodies of expressed genes. Replacing the N terminus of LEDGF with chromatin binding domains (CBDs) from other proteins changes the specificity of HIV-1 DNA integration. We chose two well-characterized CBDs: the plant hom...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0914142107

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
107
Issue:
7
Pages:
3135-3140
Publication date:
2010-02-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:548a7c59-37ca-49e0-85ac-8857313086d1
Source identifiers:
331913
Local pid:
pubs:331913

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