Journal article
<i>B</i>–N/<i>B</i>–H Transborylation: borane-catalysed nitrile hydroboration
- Abstract:
- The reduction of nitriles to primary amines is a useful transformation in organic synthesis, however, it often relies upon stoichiometric reagents or transition-metal catalysis. Herein, a borane-catalysed hydroboration of nitriles to give primary amines is reported. Good yields (48-95%) and chemoselectivity (e.g., ester, nitro, sulfone) were observed. DFT calculations and mechanistic studies support the proposal of a double B-N/B-H transborylation mechanism.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 352.3KB, Terms of use)
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- Publisher copy:
- 10.3762/bjoc.18.138
Authors
- Publisher:
- Beilstein-Institut
- Journal:
- Beilstein Journal of Organic Chemistry More from this journal
- Volume:
- 18
- Pages:
- 1332-1337
- Publication date:
- 2022-09-26
- DOI:
- EISSN:
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1860-5397
- ISSN:
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1860-5397
- Language:
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English
- Keywords:
- Pubs id:
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2364155
- UUID:
-
uuid_54698fb7-30b6-459f-a681-48fe96c6e63d
- Local pid:
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pubs:2364155
- Source identifiers:
-
W4297229299
- Deposit date:
-
2026-01-28
- ARK identifier:
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Terms of use
- Copyright date:
- 2022
- Licence:
- CC Attribution (CC BY)
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