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Journal article

Design and synthesis of acetamido tri- and tetra-hydroxyazepanes: potent and selective beta-N-acetylhexosaminidase inhibitors.

Abstract:

A series of seven-membered iminosugars bearing an acetamido group beta- or gamma- to the endocyclic nitrogen have been synthesized via simple transformations of previously described polysubstituted azepanes. These tetra- and trihydroxylated acetamido azepanes are ring homologues of 2-acetamido-1,2-dideoxy-glyconojirimycins and 2-acetamido-1-N-iminosugars respectively. Screening of these azepanes towards a range of commercially available glycosidases demonstrated their potential as selective a...

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Publication status:
Published

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Publisher copy:
10.1016/j.bmc.2009.06.022

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Journal:
Bioorganic and medicinal chemistry
Volume:
17
Issue:
15
Pages:
5598-5604
Publication date:
2009-08-05
DOI:
EISSN:
1464-3391
ISSN:
0968-0896
URN:
uuid:5460aa78-a8ef-45f9-aceb-1063b00f19df
Source identifiers:
101123
Local pid:
pubs:101123

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