Journal article
Design and synthesis of acetamido tri- and tetra-hydroxyazepanes: potent and selective beta-N-acetylhexosaminidase inhibitors.
- Abstract:
-
A series of seven-membered iminosugars bearing an acetamido group beta- or gamma- to the endocyclic nitrogen have been synthesized via simple transformations of previously described polysubstituted azepanes. These tetra- and trihydroxylated acetamido azepanes are ring homologues of 2-acetamido-1,2-dideoxy-glyconojirimycins and 2-acetamido-1-N-iminosugars respectively. Screening of these azepanes towards a range of commercially available glycosidases demonstrated their potential as selective a...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.bmc.2009.06.022
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Bibliographic Details
- Journal:
- Bioorganic and medicinal chemistry
- Volume:
- 17
- Issue:
- 15
- Pages:
- 5598-5604
- Publication date:
- 2009-08-01
- DOI:
- EISSN:
-
1464-3391
- ISSN:
-
0968-0896
- Source identifiers:
-
101123
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:101123
- UUID:
-
uuid:5460aa78-a8ef-45f9-aceb-1063b00f19df
- Local pid:
- pubs:101123
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2009
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