Journal article
A general copper-catalyzed synthesis of Ynamides from 1,2-dichloroenamides
- Abstract:
- Ynamides are accessed via copper-catalyzed coupling of Grignard or organozinc nucleophiles with chloroynamides, formed in situ from 1,2-dichloroenamides. The reaction exhibits a broad substrate scope, is readily scaled, and overcomes typical limitations in ynamide synthesis such as the use of ureas, carbamates, and bulky or aromatic amide derivatives. This modular approach contrasts with previous routes by installing both the N- and C-substituents of the ynamide as nucleophilic components.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Preview, Accepted manuscript, pdf, 921.9KB, Terms of use)
-
- Publisher copy:
- 10.1021/acs.orglett.9b00971
Authors
- Publisher:
- American Chemical Society
- Journal:
- Organic letters More from this journal
- Volume:
- 21
- Issue:
- 8
- Pages:
- 2918-2922
- Publication date:
- 2019-04-03
- Acceptance date:
- 2019-03-26
- DOI:
- EISSN:
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1523-7052
- ISSN:
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1523-7060
- Pmid:
-
30942600
- Language:
-
English
- Keywords:
- Pubs id:
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pubs:991080
- UUID:
-
uuid:545ccce8-f6fe-4902-b2e1-1ac54850466c
- Local pid:
-
pubs:991080
- Source identifiers:
-
991080
- Deposit date:
-
2019-05-17
- ARK identifier:
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2019
- Rights statement:
- © 2019 American Chemical Society
- Notes:
- This is the accepted manuscript version of the article. The final version is available from American Chemical Society at: https://doi.org/10.1021/acs.orglett.9b00971
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