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Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts.

Abstract:

BACKGROUND: Myelodysplastic syndromes are a diverse and common group of chronic hematologic cancers. The identification of new genetic lesions could facilitate new diagnostic and therapeutic strategies. METHODS: We used massively parallel sequencing technology to identify somatically acquired point mutations across all protein-coding exons in the genome in 9 patients with low-grade myelodysplasia. Targeted resequencing of the gene encoding RNA splicing factor 3B, subunit 1 (SF3B1), was also p...

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Publication status:
Published

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Publisher copy:
10.1056/nejmoa1103283

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Lab Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
New England journal of medicine
Volume:
365
Issue:
15
Pages:
1384-1395
Publication date:
2011-10-01
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Source identifiers:
192995

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