Journal article

Conversion of cysteine into dehydroalanine enables access to synthetic histones bearing diverse post-translational modifications.

Abstract:: Six for the price of one: From a single precursor, dehydroalanine, six distinct post-translational modifications can be site-selectively installed on histone proteins (see figure), including the first site-selective phosphorylation and glycosylation of histones. Direct observation of histone deacetylase activity on a full-length modified histone as well as its interactions with both chromatin reader and writer/eraser proteins are reported. © 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.

Publication status:: Published

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APA Style

Chalker, J., Lercher, L., Rose, N., Schofield, C., & Davis, B. (2012). Conversion of cysteine into dehydroalanine enables access to synthetic histones bearing diverse post-translational modifications. Angewandte Chemie (International Ed. in English), 51(8), 1835–1839.

MLA Style

Chalker, J., et al. “Conversion of Cysteine into Dehydroalanine Enables Access to Synthetic Histones Bearing Diverse Post-Translational Modifications.” Angewandte Chemie (International Ed. in English), vol. 51, no. 8, 2012, pp. 1835–39.

Chicago Style

Chalker, J, L Lercher, N Rose, C Schofield, and B Davis. 2012. “Conversion of Cysteine into Dehydroalanine Enables Access to Synthetic Histones Bearing Diverse Post-Translational Modifications.” Angewandte Chemie (International Ed. in English) 51 (8): 1835–39.
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Publisher copy:: 10.1002/anie.201106432

Authors

+ Chalker, J More by this author

Role:: Author

+ Lercher, L More by this author

Role:: Author

+ Rose, N More by this author

Role:: Author

+ Schofield, C More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Davis, B More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

Journal:: Angewandte Chemie (International ed. in English) More from this journal
Volume:: 51
Issue:: 8
Pages:: 1835-1839
Publication date:: 2012-02-01
DOI:: 10.1002/anie.201106432
EISSN:: 1521-3773
ISSN:: 1433-7851

Language:: English
Keywords:: Humans

Models, Molecular

Cysteine

Protein Processing, Post-Translational

Alkylation

Histones

Protein Conformation

Alanine
Pubs id:: pubs:237395
UUID:: uuid:5403a6a2-0fa9-4f61-8d8a-dec6b9b9b638
Local pid:: pubs:237395
Source identifiers:: 237395
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 2012

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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