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Effective connectivity of the subthalamic nucleus-globus pallidus network during Parkinsonian oscillations

Abstract:

In Parkinsonism, subthalamic nucleus (STN) neurons and two types of external globus pallidus (GP) neuron inappropriately synchronise their firing in time with slow (∼1 Hz) or beta (13-30 Hz) oscillations in cortex. We recorded the activities of STN, Type-I GP (GP-TI) and Type-A GP (GP-TA) neurons in anaesthetised Parkinsonian rats during such oscillations to constrain a series of computational models that systematically explored the effective connections and physiological parameters underlyin...

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
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Journal:
Journal of Physiology
Volume:
592
Issue:
7
Pages:
1429-1455
Publication date:
2014-04-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:53e0b25d-3f5c-4bf6-a665-287e0ffb64b5
Source identifiers:
441089
Local pid:
pubs:441089

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