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Journal article

Combined single-clade candidate HIV-1 vaccines induce T cell responses limited by multiple forms of in vivo immune interference.

Abstract:

We assessed in mice whether broad CD8+ T cell responses capable of efficient recognition of multiple HIV-1 clades could be induced using current single-clade vaccine constructs that were or will be used in clinical trials in Europe and Africa. We found that single-clade A, B and C vaccines applied alone induced only limited cross-clade reactivity and that the epitope hierarchy varied according to the immunizing clade. However, combining single-clade HIV-1 vaccines into multi-clade formulation...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200636711

Authors


Williamson, C More by this author
Williamson, AL More by this author
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Journal:
European journal of immunology
Volume:
37
Issue:
2
Pages:
566-577
Publication date:
2007-02-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:53cbfd64-7dd9-44e1-bad6-77592ecf2f1e
Source identifiers:
33730
Local pid:
pubs:33730

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