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Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.

Abstract:

A key requirement for Rab function in membrane trafficking is site-specific activation by GDP-GTP exchange factors (GEFs), but the majority of the 63 human Rabs have no known GEF. We have performed a systematic characterization of the 17 human DENN domain proteins and demonstrated that they are specific GEFs for 10 Rabs. DENND1A/1B localize to clathrin patches at the plasma membrane and activate Rab35 in an endocytic pathway trafficking Shiga toxin to the trans-Golgi network. DENND2 GEFs targ...

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Publisher copy:
10.1083/jcb.201008051

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
Journal:
The Journal of cell biology
Volume:
191
Issue:
2
Pages:
367-381
Publication date:
2010-10-05
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:53c9c692-d6ae-4b08-89fe-bb0908162333
Source identifiers:
259392
Local pid:
pubs:259392

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