Journal article icon

Journal article

Probability of transmission of malaria from mosquito to human is regulated by mosquito parasite density in naïve and vaccinated hosts

Abstract:

Over a century since Ronald Ross discovered that malaria is caused by the bite of an infectious mosquito it is still unclear how the number of parasites injected influences disease transmission. Currently it is assumed that all mosquitoes with salivary gland sporozoites are equally infectious irrespective of the number of parasites they harbour, though this has never been rigorously tested. Here we analyse >1000 experimental infections of humans and mice and demonstrate a dose-dependency f...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.ppat.1006108

Authors


Churcher, TS More by this author
More by this author
Department:
Oxford, MSD, NDM, Jenner Institute
More by this author
Department:
Oxford, MSD, NDM, Jenner Institute
More by this author
Department:
Oxford, MSD, NDM, Jenner Institute
More by this author
Department:
Oxford, MSD, NDM, Jenner Institute
Expand authors...
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
13
Issue:
1
Pages:
e1006108
Publication date:
2017-01-05
Acceptance date:
2016-12-02
DOI:
ISSN:
1553-7374
Pubs id:
pubs:670872
URN:
uri:53b028e5-4553-4c88-8b32-95e5c3590566
UUID:
uuid:53b028e5-4553-4c88-8b32-95e5c3590566
Local pid:
pubs:670872

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP