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Using structural information to change the phosphotransfer specificity of a two-component chemotaxis signalling complex.

Abstract:

Two-component signal transduction pathways comprising histidine protein kinases (HPKs) and their response regulators (RRs) are widely used to control bacterial responses to environmental challenges. Some bacteria have over 150 different two-component pathways, and the specificity of the phosphotransfer reactions within these systems is tightly controlled to prevent unwanted crosstalk. One of the best understood two-component signalling pathways is the chemotaxis pathway. Here, we present the ...

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Publication status:
Published

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Authors


Porter, SL More by this author
Strawson, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
PLoS biology
Volume:
8
Issue:
2
Pages:
e1000306
Publication date:
2010-02-05
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
URN:
uuid:539a9ab9-50a1-4207-87d8-9541bf44a059
Source identifiers:
48916
Local pid:
pubs:48916

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