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Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase.

Abstract:

Murine dendritic cells (DCs) expressing indoleamine 2,3 dioxygenase (IDO) catabolize tryptophan and can suppress T cell responses elicited in vivo. Here, we identify specific subsets of splenic (CD11c+) dendritic cells competent to mediate IDO-dependent T cell suppression following CTLA4-mediated ligation of B7 molecules. IDO-competent DC subsets acquired potent and dominant T cell suppressive properties as a consequence of IDO up-regulation, as they blocked the ability of T cells to respond ...

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Publication status:
Published

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Publisher copy:
10.1093/intimm/dxh140

Authors


Mellor, AL More by this author
Chandler, P More by this author
Hansen, AM More by this author
Marshall, B More by this author
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Journal:
International immunology
Volume:
16
Issue:
10
Pages:
1391-1401
Publication date:
2004-10-05
DOI:
EISSN:
1460-2377
ISSN:
0953-8178
URN:
uuid:53675108-ca69-4222-80ce-3c0c794aa1a4
Source identifiers:
31009
Local pid:
pubs:31009

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