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Quadrupole-time-of-flight mass spectrometer modified for higher-energy dissociation reduces protein assemblies to peptide fragments.

Abstract:

The gas-phase dissociation of protein assemblies is becoming crucial for the application of mass spectrometry to structural biology. However certain aspects of the dissociation mechanism remain elusive. Moreover, many protein complexes resist dissociation at the energies accessible with current instrumentation. Here we report new insights into the collision-induced dissociation mechanism of protein assemblies. By holding activation energy constant and varying the charge state of the precursor...

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Publication status:
Published

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Publisher copy:
10.1021/ac801950u

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
Journal:
Analytical chemistry More from this journal
Volume:
81
Issue:
3
Pages:
1270-1274
Publication date:
2009-02-01
DOI:
EISSN:
1520-6882
ISSN:
0003-2700
Language:
English
Keywords:
Pubs id:
pubs:59319
UUID:
uuid:535327de-08b2-4019-a0b4-4bed5149da69
Local pid:
pubs:59319
Source identifiers:
59319
Deposit date:
2012-12-19

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