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Sequence context effects on oligo(dT) termination signal recognition by Saccharomyces cerevisiae RNA polymerase III.

Abstract:

Eukaryotic RNA polymerase (Pol) III terminates transcription at short runs of T residues in the coding DNA strand. By genomic analysis, we found that T(5) and T(4) are the shortest Pol III termination signals in yeasts and mammals, respectively, and that, at variance with yeast, oligo(dT) terminators longer than T(5) are very rare in mammals. In Saccharomyces cerevisiae, the strength of T(5) as a terminator was found to be largely influenced by both the upstream and the downstream sequence co...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m412238200

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
The Journal of biological chemistry
Volume:
280
Issue:
20
Pages:
19551-19562
Publication date:
2005-05-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:530a56b9-74be-4677-8982-5124a8abf19e
Source identifiers:
55306
Local pid:
pubs:55306

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