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Crystals of HIV-1 reverse transcriptase diffracting to 2.2 A resolution.

Abstract:

Reverse transcriptase (RT) from the human immunodeficiency virus type 1 has been crystallized in four closely related forms, the best of which diffract X-rays to 2.2 A resolution. The RT was crystallized as a complex with a non-nucleoside inhibitor, either nevirapine or a nevirapine analogue. Crystals grew from 6% PEG 3400 buffered at pH 5. These were of space group P2(1)2(1)2(1) with unit cell parameters a = 147 A, b = 112 A, c = 79 A (form A), with one RT heterodimer in the asymmetric unit....

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Publication status:
Published

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Publisher copy:
10.1006/jmbi.1994.1604

Authors


Stammers, DK More by this author
Somers, DO More by this author
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Journal:
Journal of molecular biology
Volume:
242
Issue:
4
Pages:
586-588
Publication date:
1994-09-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:5301511f-81c7-408d-b04f-c5ec6db417d3
Source identifiers:
21132
Local pid:
pubs:21132

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