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Cell-penetrating peptide conjugates of steric blocking oligonucleotides as therapeutics for neuromuscular diseases from a historical perspective to current prospects of treatment

Abstract:

The review starts with a historical perspective of the achievements of the Gait group in synthesis of oligonucleotides (ONs) and their peptide conjugates toward the award of the 2017 Oligonucleotide Therapeutic Society Lifetime Achievement Award. This acts as a prelude to the rewarding collaborative studies in the Gait and Wood research groups aimed toward the enhanced delivery of charge neutral ON drugs and the development of a series of Arg-rich cell-penetrating peptides called Pip (peptide...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1089/nat.2018.0747

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Oxford college:
Somerville College
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Publisher:
Mary Ann Liebert Publisher's website
Journal:
Nucleic Acid Therapeutics Journal website
Volume:
29
Issue:
1
Publication date:
2018-10-16
Acceptance date:
2018-09-08
DOI:
EISSN:
2159-3345
ISSN:
2159-3337
Pubs id:
pubs:929743
URN:
uri:52fce16b-29c4-4d50-a33c-ea62cbffd33f
UUID:
uuid:52fce16b-29c4-4d50-a33c-ea62cbffd33f
Local pid:
pubs:929743

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