Dieting and weight loss in volunteers increases the number of alpha 2-adrenoceptors and 5-HT receptors on blood platelets without effect on [3H]imipramine binding.

Journal article

Platelet monoamine receptor binding was determined in normal male and female subjects before and at the end of a 2- to 3-week weight reducing diet (1200 kcal daily). Dieting was associated with an increase in platelet binding sites for both [3H]yohimbine and [125I]iodolysergic acid diethylamide (iodoLSD). The affinity at the platelet [125I]iodoLSD binding site was reduced. In contrast, [3H]imipramine binding was unchanged. These results have important implications for studies that employ platelet binding as a peripheral marker of neurotransmitter function in psychiatric illness.

Authors: Goodwin, G; Fraser, S; Stump, K; Fairburn, C; Elliott, J

• Publication status: Published
• Journal: Journal of affective disorders
• Volume: 12
• Issue: 3
• Pages: 267-274
• Publication date: 1987-01-01
• DOI: 10.1016/0165-0327(87)90037-1
• EISSN: 1573-2517
• ISSN: 0165-0327
• Language: English
• Keywords: Lysergic Acid Diethylamide; Imipramine; Humans; Yohimbine; Diet, Reducing; Receptors, Adrenergic, alpha; Binding Sites; Middle Aged; Female; Receptors, Serotonin; Male; Sex Factors; Body Weight; Blood Platelets; Adult