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Journal article

20S proteasomes have the potential to keep substrates in store for continual degradation.

Abstract:

The 20S core of the proteasome, which together with the regulatory particle plays a major role in the degradation of proteins in eukaryotic cells, is traversed by an internal system of cavities, namely two antechambers and one central proteolytic chamber. Little is known about the mechanisms underlying substrate binding and translocation of polypeptide chains into the interior of 20S proteasomes. Specifically, the role of the antechambers is not fully understood, and the number of substrate m...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m511951200

Authors


Felderer, K More by this author
Baumeister, W More by this author
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Journal:
The Journal of biological chemistry
Volume:
281
Issue:
14
Pages:
9569-9575
Publication date:
2006-04-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:52e5ffb6-71e6-4df6-ad78-2386bf88de00
Source identifiers:
59285
Local pid:
pubs:59285

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