Evidence for the persistence of monoclonal expansions of CD8+ T cells following primary simian immunodeficiency virus infection.

Journal article

A longitudinal study of the CD8+ TCR variable (Vbeta) chain repertoire was performed in rhesus macaques experimentally infected with simian immunodeficiency virus (SIV) using both TCR Vbeta chain-specific monoclonal antibodies and TCR beta chain CDR3 length analysis. Expansions of subpopulations of CD8+ T cells were detected during the acute phase of SIV infection. In all monkeys studied, monoclonal expansions persisted for at least 18 months and increasingly dominated the repertoire of CD8+ T cells expressing the relevant Vbeta chain. This study shows that persistent CD8+ T cell expansions develop in response to a virus infection. This is important not only for our understanding of the T cell response to viruses but also for understanding the factors that determine the normal CD8+ TCR repertoire.

Authors: Wilson, J; Cranage, M; Cook, N; Leech, S; Mcmichael, A

• Publication status: Published
• Journal: European journal of immunology
• Volume: 28
• Issue: 4
• Pages: 1172-1180
• Publication date: 1998-04-01
• DOI: 10.1002/(sici)1521-4141(199804)28:04<1172::aid-immu1172>3.3.co;2-b
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: T-Lymphocyte Subsets; Receptors, Antigen, T-Cell, alpha-beta; Simian Acquired Immunodeficiency Syndrome; Antibodies, Monoclonal; Cell Differentiation; Animals; Clone Cells; Simian immunodeficiency virus; CD8-Positive T-Lymphocytes