Journal article
Dengue and chikungunya virus infections among young febrile adults evaluated for acute HIV-1 infection in coastal Kenya
- Abstract:
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Background
Fever is common among patients seeking care in sub-Saharan Africa (sSA), but causes other than malaria are rarely diagnosed. We assessed dengue and chikungunya virus infections among young febrile adults evaluated for acute HIV infection (AHI) and malaria in coastal Kenya.
Methods
We tested plasma samples obtained in a cross-sectional study from febrile adult patients aged 18±35 years evaluated for AHI and malaria at urgent care seeking at seven health facilities in coastal Kenya in 2014±2015. Dengue virus (DENV) and chikungunya virus (CHIKV) were amplified using quantitative real-time reverse-transcription polymerase chain reaction. We conducted logistic regression analyses to determine independent predictors of dengue virus infection.
Results
489 samples that were negative for both AHI and malaria were tested, of which 43 (8.8%, 95% confidence interval [CI]: 6.4±11.7) were positive for DENV infection. No participant was positive for CHIKV infection. DENV infections were associated with clinic visits in the rainy season (adjusted odds ratio (AOR) = 3.0, 95% CI: 1.3±6.5) and evaluation at a private health facility (AOR 5.2, 95% CI: 2.0±13.1) or research health facility (AOR = 25.6, 95% CI: 8.9± 73.2) instead of a public health facility.
Conclusion
PA high prevalence of DENV infections was found in febrile young adult patients evaluated for AHI. Our data suggests that DENV, along with AHI and malaria, should be considered in the differential diagnosis of the adult patient seeking care for fever in coastal Kenya.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.9MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0167508
- Publisher:
- Public Library of Science
- Journal:
- PLoS One More from this journal
- Volume:
- 11
- Issue:
- 12
- Pages:
- e0167508
- Publication date:
- 2016-12-12
- Acceptance date:
- 2016-11-15
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- Pmid:
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27942016
- Language:
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English
- Keywords:
- Pubs id:
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pubs:666497
- UUID:
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uuid:5299076c-8c32-401f-a092-50dd1e4dbb99
- Local pid:
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pubs:666497
- Deposit date:
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2018-07-24
Terms of use
- Copyright holder:
- No copyright
- Copyright date:
- 2016
- Notes:
- This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
- Licence:
- CC Public Domain Dedication (CC0)
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