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AKR1D1 knockout mice develop a sex-dependent metabolic phenotype

Abstract:

Steroid 5β-reductase (AKR1D1) plays important role in hepatic bile acid synthesis and glucocorticoid clearance. Bile acids and glucocorticoids are potent metabolic regulators, but whether AKR1D1 controls metabolic phenotype in vivo is unknown. Akr1d1–/– mice were generated on a C57BL/6 background. Liquid chromatography/mass spectrometry, metabolomic and transcriptomic approaches were used to determine effects on glucocortico...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1530/joe-21-0280

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Role:
Author
ORCID:
0000-0001-5983-0306
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Role:
Author
ORCID:
0000-0002-8789-8436
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Role:
Author
ORCID:
0000-0002-7427-6603
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Name:
Medical Research Council
Grant:
MR/P011462/1
Publisher:
BioScientifica
Journal:
Journal of Endocrinology More from this journal
Volume:
253
Issue:
3
Pages:
97-113
Publication date:
2022-04-13
Acceptance date:
2022-03-23
DOI:
EISSN:
1479-6805
ISSN:
0022-0795
Pmid:
35318963
Language:
English
Keywords:
Pubs id:
1253527
Local pid:
pubs:1253527
Deposit date:
2023-01-16

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