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Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain

Abstract:

Epigenetic processes play a key role in the central nervous system and altered levels of 5-methylcytosine have been associated with a number of neurologic phenotypes, including Alzheimer's disease (AD). Recently, 3 additional cytosine modifications have been identified (5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine), which are thought to be intermediate steps in the demethylation of 5-methylcytosine to unmodified cytosine. Little is known about the frequency of these modif...

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Journal:
Neurobiology of Aging
Volume:
35
Issue:
8
Pages:
1850-1854
Publication date:
2014-01-01
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
URN:
uuid:52715e7d-6fa7-42ec-af40-c293b2efc7f9
Source identifiers:
465762
Local pid:
pubs:465762

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