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Structural remodeling of the human colonic mesenchyme in inflammatory bowel disease

Abstract:

Intestinal mesenchymal cells play essential roles in epithelial homeostasis, matrix remodeling, immunity, and inflammation. But the extent of heterogeneity within the colonic mesenchyme in these processes remains unknown. Using unbiased single-cell profiling of over 16,500 colonic mesenchymal cells, we reveal four subsets of fibroblasts expressing divergent transcriptional regulators and functional pathways, in addition to pericytes and myofibroblasts. We identified a niche population located...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.cell.2018.08.067

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-3247-3676
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
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More from this funder
Funding agency for:
Chen, HH
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Funding agency for:
Antanaviciute, A
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Publisher:
Cell Press Publisher's website
Journal:
Cell Journal website
Volume:
175
Issue:
2
Pages:
372-386.e17
Publication date:
2018-09-27
Acceptance date:
2018-08-29
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Pubs id:
pubs:923780
URN:
uri:526de786-416a-4252-bcf1-50f7ecca93fd
UUID:
uuid:526de786-416a-4252-bcf1-50f7ecca93fd
Local pid:
pubs:923780

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