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Interferon gamma: friend or foe?

Abstract:

Interferon gamma (IFN-gamma) can elicit an inflammatory TH1-driven immune response but has also been found to be necessary for long-term allograft survival induced by costimulation blockade. Recently, we have found that regulatory T cells rapidly and transiently produce IFN-gamma creating a microenvironment that can influence the function of antigen presenting cells (APCs), T-cell proliferation and activation as well as T-cell effector mechanisms, thereby controlling immune responses locally....

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
Journal:
Transplantation
Volume:
84
Issue:
1 Suppl
Pages:
S4-S5
Publication date:
2007-07-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:52488ed4-8d89-4c69-8087-b7ee781c37d6
Source identifiers:
135970
Local pid:
pubs:135970
Language:
English
Keywords:

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