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The anatomy of apathy: a neurocognitive framework for amotivated behavior

Abstract:

Apathy is a debilitating syndrome associated with many neurological disorders, including several common neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, and focal lesion syndromes such as stroke. Here, we review neuroimaging studies to identify anatomical correlates of apathy, across brain disorders. Our analysis reveals that apathy is strongly associated with disruption particularly of dorsal anterior cingulate cortex (dACC), ventral striatum (VS) and connected...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.neuropsychologia.2017.07.003

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
More from this funder
Funding agency for:
Le Heron, C
Grant:
GAF1415_CB2_ MSD_758342
More from this funder
Funding agency for:
Le Heron, C
Grant:
GAF1415_CB2_ MSD_758342
More from this funder
Funding agency for:
Husain, M
Grant:
098282
Publisher:
Elsevier Publisher's website
Journal:
Neuropsychologia Journal website
Volume:
118
Issue:
Part B
Pages:
54-67
Publication date:
2017-07-08
Acceptance date:
2017-07-06
DOI:
EISSN:
1873-3514
ISSN:
0028-3932
Source identifiers:
707652
Language:
English
Keywords:
Pubs id:
pubs:707652
UUID:
uuid:522a7048-56a1-42fb-a99d-a4f873e62594
Local pid:
pubs:707652
Deposit date:
2017-07-25

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