Journal article icon

Journal article

Arginine methylation expands the regulatory mechanisms and extends the genomic landscape under E2F control

Abstract:

E2F is a family of master transcription regulators involved in mediating diverse cell fates. Here, we show that residuespecific arginine methylation (meR) by PRMT5 enables E2F1 to regulate many genes at the level of alternative RNA splicing, rather than through its classical transcription-based mechanism. The p100/TSN tudor domain protein reads the meR mark on chromatin-bound E2F1, allowing snRNA components of the splicing machinery to assemble with E2F1. A large set of RNAs including spliced...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1126/sciadv.aaw4640

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Expand authors...
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Advances Journal website
Volume:
5
Issue:
6
Pages:
Article: eaaw4640
Publication date:
2019-06-05
Acceptance date:
2019-05-22
DOI:
ISSN:
2375-2548
Pubs id:
pubs:1025712
URN:
uri:520f44fd-dc6e-4a73-994c-59364c2511ed
UUID:
uuid:520f44fd-dc6e-4a73-994c-59364c2511ed
Local pid:
pubs:1025712

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP