Journal article
Arginine methylation expands the regulatory mechanisms and extends the genomic landscape under E2F control
- Abstract:
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E2F is a family of master transcription regulators involved in mediating diverse cell fates. Here, we show that residuespecific arginine methylation (meR) by PRMT5 enables E2F1 to regulate many genes at the level of alternative RNA splicing, rather than through its classical transcription-based mechanism. The p100/TSN tudor domain protein reads the meR mark on chromatin-bound E2F1, allowing snRNA components of the splicing machinery to assemble with E2F1. A large set of RNAs including spliced...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.9MB, Terms of use)
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- Publisher copy:
- 10.1126/sciadv.aaw4640
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Bibliographic Details
- Publisher:
- American Association for the Advancement of Science
- Journal:
- Science Advances More from this journal
- Volume:
- 5
- Issue:
- 6
- Article number:
- eaaw4640
- Publication date:
- 2019-06-05
- Acceptance date:
- 2019-05-22
- DOI:
- ISSN:
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2375-2548
Item Description
- Pubs id:
-
pubs:1025712
- UUID:
-
uuid:520f44fd-dc6e-4a73-994c-59364c2511ed
- Local pid:
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pubs:1025712
- Source identifiers:
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1025712
- Deposit date:
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2019-07-02
Terms of use
- Copyright holder:
- Roworth et al
- Copyright date:
- 2019
- Notes:
- © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY)
- Licence:
- CC Attribution (CC BY)
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