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Duplication and positive selection among hominin-specific PRAME genes.

Abstract:

The physiological and phenotypic differences between human and chimpanzee are largely specified by our genomic differences. We have been particularly interested in recent duplications in the human genome as examples of relatively large-scale changes to our genome. We performed an in-depth evolutionary analysis of a region of chromosome 1, which is copy number polymorphic among humans, and that contains at least 32 PRAME (Preferentially expressed antigen of melanoma) genes and pseudogenes. PRA...

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
BMC genomics
Volume:
6
Publication date:
2005-01-01
EISSN:
1471-2164
URN:
uuid:51e2b02d-ce75-4412-ba1b-c26f99119cbc
Source identifiers:
379682
Local pid:
pubs:379682
Language:
English

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